Stability of penicillin G in ionic liquid [Bmim]PF<sub>6</sub>

Jingxian Qi; Qingfen Liu; Huizhou Liu

doi:10.1016/j.cjche.2018.02.030

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Stability of penicillin G in ionic liquid [Bmim]PF₆

General reactor | Updated：2026-01-06

- Stability of penicillin G in ionic liquid [Bmim]PF₆
- Chinese Journal of Chemical Engineering Issue 6, Pages: 1430-1434(2018)
- Affiliations：
  
  CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences,Beijing,China,100190
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2018.02.030
  CLC：
- Published：2018
- Accepted：
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Jingxian Qi, Qingfen Liu, Huizhou Liu. Stability of penicillin G in ionic liquid [Bmim]PF₆[J]. Chinese Journal of Chemical Engineering, 2018, (6): 1430-1434. DOI: 10.1016/j.cjche.2018.02.030.
DOI：

Jingxian Qi, Qingfen Liu, Huizhou Liu. Stability of penicillin G in ionic liquid [Bmim]PF₆[J]. Chinese Journal of Chemical Engineering, 2018, (6): 1430-1434. DOI: 10.1016/j.cjche.2018.02.030. DOI：

摘要

Abstract

The extraction of penicillin G by ionic liquid [Bmim

]

has exhibited promising prospect. The stability of penicillin G is crucial for developing a green ionic liquid-based extraction technology. In this work

the stability of penicillin G in [Bmim

]

was systematically investigated. The results showed the stability of penicillin G was significantly influenced by pH and temperature. It tended to be more stable when pH value increased from 1.5 to 4.0 and the temperature gradually decreased. The half-life (t

1/2

) of penicillin G in [Bmim

]

was 17.7 h in the optimal technological condition (pH 2.0 and 10℃)

which is enough for the requirement of extraction technology. The reaction of penicillin G in [Bmim

]

followed the first order kinetics in the pH range 2.0-4.0. Three isomers of penicillin G were found through rearrangement at pH 2.0

and their structures were not affected by temperature.

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⁰

Stability of penicillin G in ionic liquid [Bmim]PF6

DOI：10.1016/j.cjche.2018.02.030

摘要

Abstract

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Stability of penicillin G in ionic liquid [Bmim]PF₆