Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Lina Zhou; Shichao Du; Ting Wang; Songgu Wu; Zhiqiang Guo; Zhao Wang; Ling Zhou

doi:10.1016/j.cjche.2017.05.002

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Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Chemical Engineering Thermodynamics | Updated：2026-01-06

- Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures
- Chinese Journal of Chemical Engineering Vol. 25, Issue 10, Pages: 1461-1466(2017)
- Affiliations：
  
  1. School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University,Tianjin,China,300072
  2. The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin,Tianjin,China,300072
  3. Tianjin Pharmaceuticals Research Institute Co. Ltd,Tianjin,China,300000
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2017.05.002
  CLC：
- Published：2017
- Accepted：
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Lina Zhou, Shichao Du, Ting Wang, Songgu Wu, Zhiqiang Guo, Zhao Wang, Ling Zhou. Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures[J]. , 2017, 25(10): 1461-1466.
DOI：

Lina Zhou, Shichao Du, Ting Wang, Songgu Wu, Zhiqiang Guo, Zhao Wang, Ling Zhou. Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures[J]. , 2017, 25(10): 1461-1466. DOI： 10.1016/j.cjche.2017.05.002.

摘要

Abstract

The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from

=(278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data

experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

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