Bi-/multi-modal pore formation of PLGA/hydroxyapatite composite scaffolds by heterogeneous nucleation in supercritical CO<sub>2</sub> foaming

Xin Xin; Yixin Guan; Shanjing Yao

doi:10.1016/j.cjche.2017.04.005

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Bi-/multi-modal pore formation of PLGA/hydroxyapatite composite scaffolds by heterogeneous nucleation in supercritical CO₂ foaming

Materials and Product Engineering | Updated：2026-01-06

- Bi-/multi-modal pore formation of PLGA/hydroxyapatite composite scaffolds by heterogeneous nucleation in supercritical CO₂ foaming
- Chinese Journal of Chemical Engineering Vol. 26, Issue 1, Pages: 207-212(2018)
- Affiliations：
  
  College of Chemical and Biological Engineering, Zhejiang University,Hangzhou,China,310027
- Author bio：
- Funds：
- DOI：10.1016/j.cjche.2017.04.005
  CLC：
- Published：2018
- Accepted：
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foaming[J]. Chinese Journal of Chemical Engineering, 2018, 26(1): 207-212.
DOI：

foaming[J]. Chinese Journal of Chemical Engineering, 2018, 26(1): 207-212. DOI： 10.1016/j.cjche.2017.04.005.

摘要

Abstract

Scaffolds with multimodal pore structure are essential to cells differentiation and proliferation in bone tissue engineering. Bi-/multi-modal porous PLGA/hydroxyapatite composite scaffolds were prepared by supercritical CO

foaming in which hydroxyapatite acted as heterogeneous nucleation agent. Bimodal porous scaffolds were prepared under certain conditions

i.e. hydroxyapatite addition of 5%

depressurization rate of 0.3 MPa·min

-1

soaking temperature of 55℃

and pressure of 9 MPa. And scaffolds presented specific structure of small pores (122 μm±66 μm) in the cellular walls of large pores (552 μm±127 μm). Furthermore

multimodal porous PLGA scaffolds with micro-pores (37 μm±11 μm) were obtained at low soaking pressure of 7.5 MPa. The interconnected porosity of scaffolds ranged from (52.53±2.69)% to (83.08±2.42)% by adjusting depressurization rate

while compression modulus satisfied the requirement of bone tissue engineering. Solvent-free CO

foaming method is promising to fabricate bi-/multi-modal porous scaffolds in one step

and bioactive particles for osteogenesis could serve as nucleation agents.

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Bi-/multi-modal pore formation of PLGA/hydroxyapatite composite scaffolds by heterogeneous nucleation in supercritical CO2 foaming

DOI：10.1016/j.cjche.2017.04.005

摘要

Abstract

关键词

Keywords

references

Bi-/multi-modal pore formation of PLGA/hydroxyapatite composite scaffolds by heterogeneous nucleation in supercritical CO₂ foaming