In this work

the kinetic study on reactive extraction of α-cyclopentylmandelic acid (α-CPMA) enantiomers was performed in a Lewis cell using hydroxyethyl-β-cyclodextrin (HE-β-CD) as chiral selector. The enantioselective complexation equilibrium between HE-β-CD and α-CPMA enantiomers was studied by phase solubility method. The important process parameters affecting the initial extraction rate were separately studied and the reaction rate equations were deduced. The optimal conditions for kinetic study were as follows:stirring speed of 75 r·min

-1

interfacial area of 12.56 cm

2

pH of 2.5

initial HE-β-CD concentration of 0.05 mol ·L

-1

initial α-CPMA concentration of 5 mmol·L

-1

and temperature of 278 K. The reaction has been found to be first order in α-CPMA and second order in HE-β-CD with the forward rate constants of 2.056×10

-3

m

6

·mol

-2

·s

-1

and 1.459×10

-3

m

6

·mol

-2

·s

-1

for (S)-α-CPMA and (R)-α-CPMA

respectively. The complexation equilibrium constants were evaluated as 61 L·mol

-1

and 117 L·mol

-1

for (S)-α-CPMA and

(R)-α-CPMA

and the intrinsic enantioselectivity is estimated as 1.92.