The polymorphismof D-Mannitol (mannitol) is reviewed in this paper. It was found that the structure of the stable form is consistent in most literatures

but different authors have given different information about the twometastable forms. Therefore the commonly used nomenclature of mannitol was summarized based on the crystal unit cell parameters with the help of X-ray powder diffraction. Moreover

the crystal growth mechanism of mannitol polymorphs was summarized. Considering the lack of kinetic data for themetastable form especially

a reportedmethod was attempted to apply to δ mannitol in an aqueous cooling crystallization process based on the induction time previouslymeasured

and itwas identified that the growth of the δ form follows the two-dimensional (2D) nucleationmediated mechanism. The results also indicate that themethod based on induction timeand supersaturation should have the potential to be expanded to the metastable polymorphs for the growth property study in a bulk system.