Recently ionic liquids (ILs) are introduced as novel dual function gas hydrate inhibitors. However

no desired gas hydrate inhibition has been reported due to poor IL selection and/or tuning method. Trial error as well as selection based on existing literature are the methods currently employed for selecting and/or tuning ILs. These methods are probabilistic

time consuming

expensive and may not result in selecting high performance ILs for gas hydrate mitigation. In this work

COSMO-RS is considered as a prescreening tool of ILs for gas hydrate mitigation by predicting the hydrogen bonding energies (E

HB

) of studied IL inhibitors and comparing the predicted E

HB

to the depression temperature (?) and induction time. Results showthat

predicted E

HB

and chain length of ILs strongly relate and significantly affect the gas hydrate inhibition depression temperature but correlate moderately (R=0.70) with average induction time in literature. It is deduced fromthe results that

? increaseswith increasing IL E

HB

and/or decreases with increasing chain length. However

the cation-anion pairing of ILs also affects IL gas hydrate inhibition performance. Furthermore

a visual and better understanding of IL/water behavior for gas

hydrate inhibition in terms of hydrogen bond donor and acceptor interaction analysis is also presented by determining the sigma profile and sigma potential of studied IL cations and anions used for gas hydrate mitigation for easy IL selection.