Wepropose a novel flowmeasurementmethod for gas-liquid two-phase slug flowby using the blind source separation technique. The flow measurementmodel is established based on the fluctuation characteristics of differential pressure (DP) signalsmeasured froma Venturimeter. It is demonstrated that DP signals of two-phase flow are a linear mixture of DP signals of single phase fluids. The measurementmodel is a combination of throttle relationship and blind source separation model. In addition

we estimate the mixturematrix using the independent component analysis (ICA) technique. The mixture matrix could be described using the variances of two DP signals acquired from two Venturi meters. The validity of the proposed model was tested in the gas-liquid twophase flow loop facility. Experimental results showed that for most slug flow the relative error is within 10%. We also find that the mixture matrix is beneficial to investigate the flow mechanism of gas-liquid two-phase flow.