Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems

Mehdi Ardjmand; Mehrdad Mirzajanzadeh; Fatemeh Zabihi

doi:10.1016/S1004-9541(14)60073-2

Your Location：

Home >

Browse articles >

Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems

催化、动力学与反应工程 | Updated：2026-01-06

- Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems
- Chinese Journal of Chemical Engineering Issue 5, Pages: 549-5581004-954160073-2(2014)
- Affiliations：
  
  1. Islamic Azad University, South Tehran Branch, Graduate Faculty, Department of Chemical Engineering, Tehran,Iran
  2. 2 Islamic Azad University, Science and Research Branch, Department of Chemical Engineering, Tehran,Iran
  3. 3 Islamic Azad University, Ayatollah Amoli Branch, Department of Chemical Engineering, Amol,Iran
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(14)60073-2
  CLC：
- Published：2014
- Accepted：
Scan QR Code
Mehdi Ardjmand, Mehrdad Mirzajanzadeh, Fatemeh Zabihi. Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems[J]. Chinese Journal of Chemical Engineering, 2014, (5): 549-5581004-954160073-2.
DOI：

Mehdi Ardjmand, Mehrdad Mirzajanzadeh, Fatemeh Zabihi. Measurement and Correlation of Solid Drugs Solubility in Supercritical Systems[J]. Chinese Journal of Chemical Engineering, 2014, (5): 549-5581004-954160073-2. DOI： 10.1016/S1004-9541(14)60073-2.

摘要

Abstract

A dynamic experimental set-up was utilized to measure ibuprofen solubility in supercritical CO

at the pressure range of 8-13 MPa and the temperatures of 308

313 and 318 K. Mole fraction values varied from 0.015×10

-3

to 3.261×10

-3

and correlated by using seven different semi empirical equations of state (Bartle

Modified Bartle

Mendez-Teja

Modified Mendez-Teja

Kumar-Johnson

Sung-shim and Gordillo) as well as seven cubic equations of state (van der Waals

Redlich-Kwong

Soave-Redlich-Kwong

Peng-Robinson

Stryjek-Vera

Patel-Teja-Valderana and Pazuki). Single and twin-parametric van der Walls mixing rules (vdW1

vdW2) were applied in order to estimate the supercritical solution properties. The physicochemical properties were also obtained using Joback

Lydersen and Ambrose methods. Absolute average relatives deviation (AARD) were calculated and compared for all the correlating systems. Results showed that among the cubic equations of state (EOSs) the Pazuki equation (AARD 19.85% using vdW1 and AARD 8.79% using vdW2) and SRK equation (AARD 19.20% using vdW1 and AARD 10.03% using vdW2) predicted the ibuprofen solubility in supercritical CO

with the least error in comparison to the others. Among the semi-empir

ical EOSs the most desirable deviation (AARD10%) was obtained by using Modified Bartle and Modified Mendez-Teja equations in all the studied temperatures.

关键词

Keywords

references

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Solubility of iron(III) and nickel(II) acetylacetonates in supercritical carbon dioxide

Synergistically coupling of vertically oriented Ru/Co co-doped MoS2 with interfacial engineering for efficient electrochemical hydrogen evolution

Optimizing energy efficiency in fluid catalytic cracking units with GA and NSGA-II: A comprehensive simulation and multi-factor analysis

Biochar as a structure-tunable stationary phase for column chromatographic fractionation of bio-oil

Research on the electrostatic spray characteristics of ethanol/n-butanol blended fuels

Related Author

Haixin Sun

Jianlei Qi

Jianfei Sun

Lin Li

Kunpeng Yu

Jintao Wu

Jianzhong Yin

Related Institution

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology

College of Chemical Engineering, Inner Mongolia University of Technology

⁰