Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid

王仁敏; 林婵; 刘晶靓; 余方; 高建培; 潘学军

doi:10.1016/S1004-9541(12)60375-9

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Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid

Updated：2026-01-06

- Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid
- Chinese Journal of Chemical Engineering Vol. 20, Issue 1, Pages: 152-157(2012)
- Affiliations：
  
  Faculty of Environmental Science and Engineering, Kunming University of Science and Technology,Kunming,China,650093
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(12)60375-9
  CLC： TQ464
- Published：2012
- Accepted：
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WANG Renmin, LIN Chan, LIU Jingliang, YU Fang, GAO Jianpei, PAN Xuejun. Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid[J]. Chin.J.Chem.Eng., 2012, 20(1): 152-157.
DOI：

WANG Renmin, LIN Chan, LIU Jingliang, YU Fang, GAO Jianpei, PAN Xuejun. Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid[J]. Chin.J.Chem.Eng., 2012, 20(1): 152-157. DOI： 10.1016/S1004-9541(12)60375-9.

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Abstract

A pressured microwave-assisted hydrolysis(PMAH) technique has been developed for hydrolyzing the crude glycyrrhizic acid(GA) extracted from licorice root to prepare glycyrrhetinic acid(GRA).In order to optimize the efficiency of PMAH

several experimental parameters were investigated

including liquid-solid ratio

hydrolysis time

sulfuric acid concentration and hydrolysis temperature.The optimized hydrolysis conditions were as follows:pressured microwave-assisted hydrolysis of crude GA for 21 min(taking 15 min to reach 150℃

and holding it for 6 min) at 150℃(at a radiation power of 450 W) in 3%-5% sulfuric acid solution with the liquid-solid(ml·g

-1

crude GA) ratio of 25:1.As a result of the considerable saving in time and higher product yields(up to 90%)

PMAH was proved more effective than conventional methods.

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