Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance

焦真; 陈志明; 吴有庭; 马少玲

doi:10.1016/S1004-9541(11)60159-6

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Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance

Updated：2026-01-06

- Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance
- Chinese Journal of Chemical Engineering Vol. 19, Issue 2, Pages: 227-231(2011)
- Affiliations：
  
  1. School of Chemistry and Chemical Engineering, Southeast University,Nanjing,China,211189
  2. School of Chemistry and Chemical Engineering, Nanjing University,Nanjing,China,210093
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(11)60159-6
  CLC：
- Published：2011
- Accepted：
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JIAO Zhen, CHEN Zhiming, WU Youting, MA Shaoling. Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance[J]. , 2011, 19(2): 227-231.
DOI：

JIAO Zhen, CHEN Zhiming, WU Youting, MA Shaoling. Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance[J]. , 2011, 19(2): 227-231. DOI： 10.1016/S1004-9541(11)60159-6.

摘要

Abstract

A quartz crystal microbalance (QCM) is used to determine the phase equilibrium of paclitaxel-carbon dioxide system in the pressure range of 0-11 MPa and at temperatures of 35℃

40℃ and 45℃.The experimental results indicated that gaseous CO

could be absorbed poorly into paclitaxel.The swelling of paclitaxel film in CO

was observed before paclitaxel dissolved into supercritical carbon dioxide (ScCO

) with the increase of pressure.It was found that ScCO

was not a good solvent for paclitaxel.The mole fraction of paclitaxel in ScCO

was in the range of (4.5×10

-9

)-(7.8×10

-9

) under all our experimental conditions.Therefore

a much higher pressure than the CO

supercritical point and/or a cosolvent must be used in any processes wherever paclitaxel dissolution in ScCO

is required.

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