Efficient Separation of Butyric Acid by an Aqueous Two-phase System with Calcium Chloride

吴丹; 陈灏; 江凌; 蔡谨; 徐志南; 岑沛霖

doi:10.1016/S1004-9541(10)60255-8

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Efficient Separation of Butyric Acid by an Aqueous Two-phase System with Calcium Chloride

Updated：2026-01-06

- Efficient Separation of Butyric Acid by an Aqueous Two-phase System with Calcium Chloride
- Chinese Journal of Chemical Engineering Vol. 18, Issue 4, Pages: 533-537(2010)
- Affiliations：
  
  Department of Chemical and Biological Engineering, Zhejiang University,Hangzhou,China,310027
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(10)60255-8
  CLC：
- Published：2010
- Accepted：
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WU Dan, CHEN Hao, JIANG Ling, CAI Jin, XU Zhinan, CEN Peilin. Efficient Separation of Butyric Acid by an Aqueous Two-phase System with Calcium Chloride[J]. , 2010, 18(4): 533-537.
DOI：

WU Dan, CHEN Hao, JIANG Ling, CAI Jin, XU Zhinan, CEN Peilin. Efficient Separation of Butyric Acid by an Aqueous Two-phase System with Calcium Chloride[J]. , 2010, 18(4): 533-537. DOI： 10.1016/S1004-9541(10)60255-8.

摘要

Abstract

One of the bottlenecks for bioproduction of butyric acid as bulk chemical is the difficulty in separating butyric acid from the fermentation broth

compared with the petroleum-based chemical synthesis method.In the present work

a novel separation methodology was developed based on an aqueous two-phase system with inor-ganic salts.Calcium chloride was screened out for effective separation of butyric acid from butyric acid-water-salt systems.Within appropriate concentration range of butyric acid and salt

butyric acid was enriched in the upper phase and most of calcium ions remained in the lower phase.This"salting out"effect is very efficient to separate butyric acid from the simulated butyrate fermentation broth

which consists of butyric acid and acetic acid with concentration ratio of 4:1

so that the final ratio of butyric acid/acetic acid in the upper phase is improved to 9.87. The aqueous two-phase system was used to separate butyric acid from the actual fermentation broth with satisfactory result.

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