Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants

唐课文; 苗家兵; 周涛; 刘永兵

doi:10.1016/S1004-9541(09)60227-5

Your Location：

Home >

Browse articles >

Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants

评述 | Updated：2026-01-06

- Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilic β-CD Derivatives Extractants
- Chinese Journal of Chemical Engineering Vol. 19, Issue 3, Pages: 397-403(2011)
- Affiliations：
  
  College of Chemistry and Chemical Engineering, Central South University,Changsha,China,410083
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(09)60227-5
  CLC：
- Published：2011
- Accepted：
Scan QR Code
-CD Derivatives Extractants[J]. Chinese Journal of Chemical Engineering, 2011, 19(3): 397-403.
DOI：

-CD Derivatives Extractants[J]. Chinese Journal of Chemical Engineering, 2011, 19(3): 397-403. DOI： 10.1016/S1004-9541(09)60227-5.

摘要

This paper deals with the enantioseparation of phenylsuccinic acid(H

A)enantiomers by liquid-liquid reactive extraction using β-CD derivatives as aqueous selectors.Cyclodextrin and its derivatives can interact with guest molecules selectively to form complexes with different stabilities.Cyclodextrin derivatives are not soluble in organic liquids

but highly soluble in water.In this work

hydroxypropyl-β-cyclodextrin(HP-β-CD)

hydroxyethylβ-cyclodextrin(HE-β-CD)and methyl-β-cyclodextrin(Me-β-CD)were selected as chiral selectors in aqueous phase for the reactive extraction of phenylsuccinic acid enantiomers from organic phase to aqueous phase.The results show that the efficiency of the extraction depends

often strongly

on a number of process variables

including the types of organic solvents and β-CD derivatives

the concentrations of the extractants and H

A enantiomers

pH and temperature.HP-β-CD

HE-β-CD and Me-β-CD have stronger recognition abilities for R-phenylsuccinic acid than for S-phenylsuccinic acid.Among the three kinds of β-CD derivatives

HP-β-CD has the strongest separation ability. Excellent enantioseparation was achieved under the optimal conditions of pH of 2.5 and temperature of 5℃ with a maximum enantioselectivity(a)of 2.38.Reactive extraction of enantiomers with hydrophilic β-CD derivatives is of strong chiral separation ability and can be hopeful for separations of various enantiomers at a large-scale.

Abstract

This paper deals with the enantioseparation of phenylsuccinic acid(H

A)enantiomers by liquid-liquid reactive extraction usingβ-CD derivatives as aqueous selectors.Cyclodextrin and its derivatives can interact with guest molecules selectively to form complexes with different stabilities.Cyclodextrin derivatives are not soluble in organic liquids

but highly soluble in water.In this work

hydroxypropyl-β-cyclodextrin(HP-β-CD)

hydroxyethyl β-cyclodextrin(HE-β-CD)and methyl-β-cyclodextrin(Me-β-CD)were selected as chiral selectors in aqueous phase for the reactive extraction of phenylsuccinic acid enantiomers from organic phase to aqueous phase.The results show that the efficiency of the extraction depends

often strongly

on a number of process variables

including the types of organic solvents and β-CD derivatives

the concentrations of the extractants and H

A enantiomers

pH and temperature.HP-β-CD

HE-β-CD and Me-β-CD have stronger recognition abilities for R-phenylsuccinic acid than for S-phenylsuccinic acid.Among the three kinds of β-CD derivatives

HP-β-CD has the strongest separation ability. Excellent enantioseparation was achieved under the optimal conditions of pH of 2.5 and temperature of 5℃ wi

th a maximum enantioselectivity(a)of 2.38.Reactive extraction of enantiomers with hydrophilic β-CD derivatives is of strong chiral separation ability and can be hopeful for separations of various enantiomers at a large-scale.

关键词

Keywords

references

Views

1353

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Recovery rubidium chloride and cyclic utilization of hexacyanoferrate(II) ion from hexacyanoferrate-internediate solutions via solvent extraction

Highly enhanced scandium extraction and back-extraction efficiencies using a new C272—iso-octanol synergistic system

Selective separation of vanadium from the high-acidity leaching liquor through chelating extraction by the ketoxime extractant

Separation and recovery of V/W/Na from waste SCR catalyst leaching solution using membrane electrolysis—Ion morphology pretreatment solvent extraction-stripping method

Design method of extractant for liquid-liquid extraction based on elements and chemical bonds

Related Author

Li Chenxi

Li Kang

Li Shina

Ma Ruixin

Zhang Ziyun

Zhang Yanlin

Shen Wenyu

Guo Dapeng

Related Institution

Beijing Key Laboratory of Special Melting and Preparation of High-end Metal Materials

Tianjin Research Institute of Water Transport Engineering, Ministry of Transport

School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing

Institute of Process Engineering, Chinese Academy of Sciences

School of Resources and Safety Engineering, Wuhan Institute of Technology

⁰