Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers

李小军; 尹明辉; 张国亮; 张凤宝

doi:10.1016/S1004-9541(09)60046-X

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Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers

Updated：2026-01-06

- Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers
- Chinese Journal of Chemical Engineering Vol. 17, Issue 1, Pages: 145-149(2009)
- Affiliations：
  
  School of Chemical Engineering and Technology, Tianjin University,Tianjin,China,300072
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(09)60046-X
  CLC：
- Published：2009
- Accepted：
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LI Xiaojun, YIN Minghui, ZHANG Guoliang, ZHANG Fengbao. Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers[J]. , 2009, 17(1): 145-149.
DOI：

LI Xiaojun, YIN Minghui, ZHANG Guoliang, ZHANG Fengbao. Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers[J]. , 2009, 17(1): 145-149. DOI： 10.1016/S1004-9541(09)60046-X.

摘要

In this study

double-hydrophilic hydroxylpropyl cellulose(HPC) based copolymers with poly(N-isopropylacrylamide)(PNIPAM) and poly(acrylic acid)(PAA) as graft chains were synthesized and characterized.The release behavior of drug-loaded micelles was studied.The results show that the hydrophilicity of copolymers improves as the pH increases

whereas the hydrophobicity of copolymers enhances as the temperature increases

and all the phase behaviors are reversible.The diameter of micelles decreases and then increases with pH increase.It shows different micellizing behavior under acidic and basic conditions accor

ding to the temperature increase.

In vitro

release experiments

which used theophylline as a model drug

show that the micelles enhance pH sensitivity in the release process.

Abstract

In this study

whereas the hydrophobicity of copolymers enhances as the temperature increases

and all the phase behaviors are reversible.The diameter of micelles decreases and then increases with pH increase.It shows different micellizing behavior under acidic and basic conditions according to the temperature increase.

In vitro

release experiments

which used theophylline as a model drug

show that the micelles enhance pH sensitivity in the release process.

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