Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

赵宏; 王洁欣; 张海霞; 沈志刚; 甄崇礼; 陈建峰

doi:10.1016/S1004-9541(08)60210-4

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Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

Updated：2026-01-06

- Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method
- Chinese Journal of Chemical Engineering Vol. 17, Issue 2, Pages: 318-323(2009)
- Affiliations：
  
  1. China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing,Sin,China,10029
  2. Nanomaterials Technology Pte. Ltd.,Singapore
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(08)60210-4
  CLC：
- Published：2009
- Accepted：
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ZHAO Hong, WANG Jiexin, ZHANG Haixia, SHEN Zhigang, Jimmy Yun, CHEN Jianfeng. Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method[J]. , 2009, 17(2): 318-323.
DOI：

ZHAO Hong, WANG Jiexin, ZHANG Haixia, SHEN Zhigang, Jimmy Yun, CHEN Jianfeng. Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method[J]. , 2009, 17(2): 318-323. DOI： 10.1016/S1004-9541(08)60210-4.

摘要

Abstract

The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation(HGAP) process.Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment(rotating packed bed) in carrying out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles.The Brunauer-Emmett-Teller(BET) surface area sharply increases from 0.66 m

·g

-1

to 15.08 m

·g

-1

.Accordingly

the dissolution rate is greatly improved.The molecular state

chemical composition

and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The high recovery ratio and continuous production capacity are highly appreciated in industry.Therefore

the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.

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