Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

续京; 刘晓林; 陈建峰

doi:10.1016/S1004-9541(08)60157-3

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Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

Updated：2026-01-06

- Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant
- Chinese Journal of Chemical Engineering Vol. 16, Issue 5, Pages: 791-795(2008)
- Affiliations：
  
  1. Ningxia University,Yinchuan,China,750021
  2. Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University ofChemical Technology,Beijing,China,100029
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(08)60157-3
  CLC：
- Published：2008
- Accepted：
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XU Jing, LIU Xiaolin, CHEN Jianfeng. Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant[J]. , 2008, 16(5): 791-795.
DOI：

XU Jing, LIU Xiaolin, CHEN Jianfeng. Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant[J]. , 2008, 16(5): 791-795. DOI： 10.1016/S1004-9541(08)60157-3.

摘要

Abstract

The preparation of ultra-fine particles of salbutamol sulphate(SS)was accomplished with a reactive precipitation pathway

in which salbutamol and sulphuric acid were used as reactants with the solvents of ethanol. The effects of sulphuric acid concentration

reaction temperature

stirring rate

and reaction time on the size of the particle were investigated.A binary mixture composed of lactose and SS was prepared to evaluate SS.The results showed that ultra-fine SS particles with controlled diameters ranging between 3μm and 0.8μm and with a narrow distribution could be achieved.The morphology consisting of clubbed particles was successfully obtained.The purity of the particles reached above 98% with UV detection.The dose of dry powder inhalation was obtained by blending the particles with recrystallized lactose

which acted as a carrier.The deposition quantity of the drug in breathing tract was estimated using a twin impinger apparatus.Compared with the Shapuer powder(purchased in the market)

the results showed that SS particles had more quantities subsided in simulative lung.

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