Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels

黎新明; 崔英德

doi:10.1016/S1004-9541(08)60134-2

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Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels

Updated：2026-01-06

- Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels
- Chinese Journal of Chemical Engineering Vol. 16, Issue 4, Pages: 640-645(2008)
- Affiliations：
  
  School of Chemistry, Chemical Engineering, Zhongkai University of Agriculture, Engineering,Guangzhou,China,510225
- Author bio：
- Funds：
- DOI：10.1016/S1004-9541(08)60134-2
  CLC：
- Published：2008
- Accepted：
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LI Xinming, CUI Yingde. Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels[J]. , 2008, 16(4): 640-645.
DOI：

LI Xinming, CUI Yingde. Study on Synthesis and Chloramphenicol Release of Poly(2-hydroxyethylmethacrylate-co-acrylamide)Hydrogels[J]. , 2008, 16(4): 640-645. DOI： 10.1016/S1004-9541(08)60134-2.

摘要

Abstract

In this article

poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels were synthesized by bulk free-radical copolymerization of 2-hydroxyethylmethacrylate (HEMA) and acrylamide (AAm) for soft contact lens(SCL)-based ophthalmic drug delivery system. The copolymer was characterized with FT-IR and SEM

the swelling property of the hydrogels were studied by gravimetrical method

and chloramphenicol was used as a model drug to investigate drug release profile of the hydrogels. The results showed that poly(2-hydroxyethylmethacrylate-co-acrylamide) hydrogels were transparent and useful SCL biomaterial

the water content increased as AAm content increase and pH decrease

and in the same way

hydrogel composition affected chloramphenicol release process too. Migration rate of chloramphenicol increased as the AAm content in the hydrogels increased in the first stage of diffusion process

whereas there was no significant difference thereafter.

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