Towards understanding the mechanism of <i>n</i>-hexane tolerance in <i>Synechocystis</i> sp. PCC 6803

Tao Sun; Shubin Li; Guangsheng Pei; Lei Chen; Weiwen Zhang

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Towards understanding the mechanism of n-hexane tolerance in Synechocystis sp. PCC 6803

Full Length Article | Updated：2026-01-06

- Towards understanding the mechanism of n-hexane tolerance in Synechocystis sp. PCC 6803
- Chinese Journal of Chemical Engineering Vol. 59, Issue 7, Pages: 128-134(2023)
- Affiliations：
  
  1. Laboratory of Synthetic Microbiology, School of Chemical Engineering & Technology, Tianjin University,Tianjin,China,300072
  2. Frontier Science Center for Synthetic Biology & Key Laboratory of Systems Bioengineering, Ministry of Education of China,Tianjin,China,300072
  3. Center for Biosafety Research and Strategy, Tianjin University,Tianjin,China,300072
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2023
- Accepted：
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摘要

Abstract

Synthetic biology efforts have also led to the development of photosynthetic cyanobacteria as “autotrophic cell factories” for biosynthesis of various biofuels directly from CO

. However

the low tolerance to toxicity of biofuels has restricted the economic application of cyanobacterial hosts. In this study

RNA-seq transcriptomics was employed to reveal stress responses to exogenous

-hexane in

Synechocystis

sp. PCC 6803. Functional enrichment analysis of the transcriptomic data showed that signal transduction systems were induced significantly. To further identify regulatory genes related to

-hexane tolerance

a library of transcriptional regulators (TRs) deletion mutants was then screened for their roles in

-hexane tolerance. The results showed that a knockout mutant of

slr0724

that encodes an HtaR suppressor protein was more tolerant to

-hexane than the wild type

indicating the involvement of

slr0724

-hexane tolerance. This study provides the foundation for better understanding the cellular responses to

-hexane in

Synechocystis

sp. PCC 6803

which could contribute to the further engineering of

-hexane tolerance in cy

anobacteria.

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Related Institution

Pharmaceutical Informatics Institute, College of Pharmaceutical Science, Zhejiang University

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Towards understanding the mechanism of n-hexane tolerance in Synechocystis sp. PCC 6803

DOI：

摘要

Abstract

关键词

Keywords

references