Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Baolong Niu; Min Li; Jianhong Jia; Lixuan Ren; Xin Gang; Bin Nie; Yanying Fan; Xiaojie Lian; Wenfeng Li

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Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Updated：2026-01-06

- Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers
- Chinese Journal of Chemical Engineering Vol. 48, Issue 8, Pages: 244-252(2022)
- Affiliations：
  
  1. College of Materials Science and Engineering, Taiyuan University of Technology,Taiyuan,China,030024
  2. Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology,Taiyuan,China,030024
  3. School of Basic Medical Sciences, Shanxi Medical University,Taiyuan,China,030001
  4. Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology,Taiyuan,China,030024
  5. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology,Taiyuan,China,030024
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2022
- Accepted：
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Baolong Niu, Min Li, Jianhong Jia, Lixuan Ren, Xin Gang, Bin Nie, Yanying Fan, Xiaojie Lian, Wenfeng Li. Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers[J]. Chinese Journal of Chemical Engineering, 2022, 48(8): 244-252.
DOI：

Baolong Niu, Min Li, Jianhong Jia, Lixuan Ren, Xin Gang, Bin Nie, Yanying Fan, Xiaojie Lian, Wenfeng Li. Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers[J]. Chinese Journal of Chemical Engineering, 2022, 48(8): 244-252. DOI：

摘要

Abstract

Recently

multifunctional nanoparticles have shown great prospects in cancer treatment

which have the ability to simultaneously deliver the drug

image and target tumor cells. In this paper

we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate (HA-FCNs/ACP) with multifunctional properties for drug delivery

bio-imaging

and targeting treatment. HA-FCNs/ACP shows an ability to load curcumin (Cur) with pH-sensitive responsive drug release behavior and excellent biocompatibility. HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells (A549 cells). Meanwhile

the viability of A549 cells was significantly inhibited

in vitro

. The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells. Hence

the as-prepared nanoparticles have promising applications in treating tumor disease.

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