Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide

Yue Wang; Luyao Huan; Haiyan Liang; Xuejia Ding; Jianguo Mi

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Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide

Full Length Article | Updated：2026-01-06

- Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide
- Chinese Journal of Chemical Engineering Vol. 47, Issue 7, Pages: 245-253(2022)
- Affiliations：
  
  1. Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, No. 2, Yinghuayuandong Road,Beijing,China,100029
  2. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, No. 15, Beisanhuandong Road,Beijing,China,100029
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2022
- Accepted：
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Yue Wang, Luyao Huan, Haiyan Liang, Xuejia Ding, Jianguo Mi. Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide[J]. Chinese Journal of Chemical Engineering, 2022, 47(7): 245-253.
DOI：

Yue Wang, Luyao Huan, Haiyan Liang, Xuejia Ding, Jianguo Mi. Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide[J]. Chinese Journal of Chemical Engineering, 2022, 47(7): 245-253. DOI：

摘要

Abstract

Tubal pregnancy is a common abnormal pregnancy manifestation

and the ordinary conservative treatment of tubal adhesion usually leads to the rupture of fallopian tube

which increases the risk of a second ectopic pregnancy. To avoid this symptom

it is suitable to implant a stent to separate the adhesion. Here we prepared the PBAT/PLGA foam as the stent material using supercritical CO

foaming technology. With uniform macroporous structure and thin-wall feature

the foam possessed low compressive modulus in prevention of the possible second injury to the fallopian tube. The introduction of PLGA 50/50 improved the biodegradable capability of the foam

with a mass loss about 20% after a 12-week hydrolysis. After implanted into the ruptured fallopian tube of the rabbit model

the foam displayed excellent biocompatibility

and provided a good support to prevent tubal adhesion. As such

this work provides the foam material as a promising candidate for fallopian tube stent to remedy the tubal adhesion.

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