Current advances of biocontainment strategy in synthetic biology

Xueying Zhu; Zhaoyang Zhang; Bin Jia; Yingjin Yuan

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Current advances of biocontainment strategy in synthetic biology

Review | Updated：2026-01-06

- Current advances of biocontainment strategy in synthetic biology
- Chinese Journal of Chemical Engineering Vol. 56, Issue 4, Pages: 141-151(2023)
- Affiliations：
  
  Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University,Tianjin,China,300072
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2023
- Accepted：
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Xueying Zhu, Zhaoyang Zhang, Bin Jia, Yingjin Yuan. Current advances of biocontainment strategy in synthetic biology[J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 141-151.
DOI：

Xueying Zhu, Zhaoyang Zhang, Bin Jia, Yingjin Yuan. Current advances of biocontainment strategy in synthetic biology[J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 141-151. DOI：

摘要

Abstract

Synthetic biotechnology has led to the widespread application of genetically modified organisms (GMOs) in biochemistry

bioenergy

and therapy. However

the uncontrolled spread of GMOs may lead to genetic contamination by horizontal gene transfer

resulting in unpredictable biosafety risks. To deal with these challenges

many effective methods have been developed for biocontainment. In this article

we summarize and discuss recent advances in biocontainment strategies from three aspects: DNA replication

transcriptional regulation

and protein translation. We also briefly introduce the efforts in the biocontainment convention

such as the recent publication of the Tianjin Biosecurity Guidelines for the Code of Conduct for Scientists.

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