Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging

Jingran Liu; Yue Wu; Jie Tang; Tao Wang; Feng Ni; Qiumin Wu; Xijiao Yang; Ayyaz Ahmad; Naveed Ramzan; Yisheng Xu

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Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging

Full Length Article | Updated：2026-01-06

- Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging
- Chinese Journal of Chemical Engineering Vol. 56, Issue 4, Pages: 89-96(2023)
- Affiliations：
  
  1. State Key Laboratory of Chemical Engineering, East China University of Science and Technology,Shanghai,China,200237
  2. Shanghai Shyndec Pharmaceutical Co., Ltd,Shanghai,China,200040
  3. Department of Chemical Engineering, Muhammad Nawaz Sharif University of Engineering and Technology,Multan,Pakistan
  4. Faculty of Chemical, Metallurgical, and Polymer Engineering, University of Engineering & Technology,Lahore,Pakistan
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2023
- Accepted：
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Jingran Liu, Yue Wu, Jie Tang, Tao Wang, Feng Ni, Qiumin Wu, Xijiao Yang, Ayyaz Ahmad, Naveed Ramzan, Yisheng Xu. Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging[J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 89-96.
DOI：

Jingran Liu, Yue Wu, Jie Tang, Tao Wang, Feng Ni, Qiumin Wu, Xijiao Yang, Ayyaz Ahmad, Naveed Ramzan, Yisheng Xu. Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging[J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 89-96. DOI：

摘要

Abstract

Traditional fluorescence switching molecules achieving the state change between on and off states commonly based on UV irradiation. However

it is worth noting that UV irradiation is harmful to both the cancer cells and the normal cells. To achieve fluorescence switching under visible wavelength and avoid complicate molecular design

a fluorophore of 2

6-tetrakis(carbazol-9-yl)-1

3-dicyanobenzene (4CzIPN) and a quencher of diarylethene (DAE) were physically incorporated within the biocompatible block copolymer poly(lactic-co-glycolic acid)-

-poly(ethylene glycol) (PLGA-

-PEG) to form 4CzIPN-DAE nanoparticles (NPs) through flash nanoprecipitation (FNP). By using the FNP method

the NPs were prepared within milliseconds in a confined impingement jets dilution (CIJ-D) mixer. Quenching and recovery of fluorescence could achieve in the presence of DAE under 475 nm and 560 nm irradiation. Appropriate structure and fluorescent properties of the nanoparticles can be tuned by external conditions for their efficient fluorescence resonance energy transfer (FRET) in a kinetic stabilization process. This NPs formation process was further optimized by varying the dilution

ratio

Reynolds number (

) and polymer concentration to modulate the mixing and particle nucleation and growth process. The size and fluorescence switching properties of the NPs were systematically investigated in solution and in cellular uptake experiments. This work is anticipated to provide a simple and highly effective engineering strategy for the modulation of fluorescence switching nanoparticles and beneficial to its engineering application.

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