Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties <i>via</i> green foaming strategy

Chaobo Song; Jiapeng Zhang; Shuang Li; Shengbin Yang; Eryi Lu; Zhenhao Xi; Lian Cen; Ling Zhao; Weikang Yuan

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Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

Materials and Product Engineering | Updated：2026-01-06

- Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy
- Chinese Journal of Chemical Engineering Vol. 29, Issue 1, Pages: 426-436(2021)
- Affiliations：
  
  1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology,Shanghai,China,200237
  2. Department of Stomatology of Renji Hospital, School of Medicine, Shanghai Jiao Tong University,Shanghai,China,200127
  3. Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhizaoju Road,Shanghai,China,200011
- Author bio：
- Funds：
- DOI：
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- Published：2021
- Accepted：
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green foaming strategy[J]. 中国化学工程学报, 2021, 29(1): 426-436.
DOI：

green foaming strategy[J]. 中国化学工程学报, 2021, 29(1): 426-436. DOI：

摘要

Abstract

In this study

mesoporous bioactive glass particles (MBGs) are incorporated into poly(lactic-co-glycolic acid) (PLGA) to fabricate highly interconnected macroporous composite scaffolds with enhanced mechanical and biological properties

via

a developed supercritical carbon dioxide (scCO

) foaming method. Scaffolds show favorable highly interconnected and macroporous structure through a high foaming pressure and long venting time foaming strategy. Specifically

scaffolds with porosity from 73% to 85%

pore size from 120 μm to 320 μm and interconnectivity of over 95% are controllably fabricated at MBG content from 0 wt% to 20 wt%. In comparison with neat PLGA scaffolds

composite scaffolds perform improved strength (up to 1.5 folds) and Young's modulus (up to 3 folds). The interconnected macroporous structure is beneficial to the ingrowth of cells. More importantly

composite scaffolds also provide a more promising microenvironment for cellular proliferation and adhesion with the release of bioactive ions. Hopefully

MBG/PLGA scaffolds developed by the green foaming strategy in this work show promising morphological

mechanical and biologi

cal features for tissue regeneration.

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Highly interconnected macroporous MBG/PLGA scaffolds with enhanced mechanical and biological properties via green foaming strategy

DOI：

摘要

Abstract

关键词

Keywords

references