Monoclonal antibody-based cancer therapies

Yingnan Si; Arin L. Melkonian; Keegan C. Curry; Yuanxin Xu; Maranda Tidwell; Mingming Liu; Ahmed F. Zaky; Xiaoguang (Margaret) Liu

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Monoclonal antibody-based cancer therapies

Biomedical Engineering | Updated：2026-01-06

- Monoclonal antibody-based cancer therapies
- Chinese Journal of Chemical Engineering Vol. 29, Issue 2, Pages: 301-307(2021)
- Affiliations：
  
  1. Department of Biomedical Engineering, University of Alabama at Birmingham(UAB), 1825 University Blvd,AL,Birmingham,USA,35294
  2. nd Ave S.,AL,Birmingham,USA,35294
  3. Chinese Medicine Hospital, 98 Shengcheng Street, Shouguang,China,262700
  4. Department of Anesthesiology and Perioperative Medicine, UAB, 625 19th Street South,AL,Birmingham,USA,35294
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2021
- Accepted：
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Yingnan Si, Arin L. Melkonian, Keegan C. Curry, Yuanxin Xu, Maranda Tidwell, Mingming Liu, Ahmed F. Zaky, Xiaoguang (Margaret) Liu. Monoclonal antibody-based cancer therapies[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 301-307.
DOI：

Yingnan Si, Arin L. Melkonian, Keegan C. Curry, Yuanxin Xu, Maranda Tidwell, Mingming Liu, Ahmed F. Zaky, Xiaoguang (Margaret) Liu. Monoclonal antibody-based cancer therapies[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 301-307. DOI：

摘要

Abstract

Targeted therapy has been widely demonstrated as an effective strategy to treat cancers

the leading cause of death in the world. This minireview summarizes the technical platforms and methodologies utilized to develop and engineer therapeutic monoclonal antibodies and antibody-drug conjugates. First

the USA FDA approved monoclonal antibody (mAb)-based targeted therapies are reviewed. Then the representative innovative chimeric

humanized and fully human anti-cancer antibodies and antibody-drug conjugates are described. Finally

the past and predictive market trend of therapeutic antibodies is discussed.

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