Zearalenone (ZEN) is a widely distributed mycotoxin that frequently contaminates crops and animal feed. ZEN can cause serious health problems in livestock and humans alike

leading to great economic losses in the food industry and livestock farming. Therefore

approaches for efficient ZEN decontamination in food and feed are urgently needed. Traditional physical and chemical methods may decrease the nutritional quality of food and palatability of feed

or leading to residues and safety concerns. By contrast

biological methods for the removal or degradation of ZEN overcome these problems

especially for biological degradation by microorganisms and specific enzymes extracted from strains that can convert ZEN to less toxic or even completely harmless products. In this review

we comprehensively describe methods for ZEN degradation

focusing especially on biological strategies. Finally

emerging strategies and advice on remaining challenges in biodegradation research are also briefly discussed.