Engineered microorganisms and enzymes for efficiently synthesizing plant natural products

Wenqiang Li; Wentao Sun; Chun Li

Your Location：

Home >

Browse articles >

Engineered microorganisms and enzymes for efficiently synthesizing plant natural products

Synthetic Biotechnology and Metabolic Engineering | Updated：2026-01-06

- Engineered microorganisms and enzymes for efficiently synthesizing plant natural products
- Chinese Journal of Chemical Engineering Vol. 29, Issue 2, Pages: 62-73(2021)
- Affiliations：
  
  Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University,Beijing,China,100084
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2021
- Accepted：
Scan QR Code
Wenqiang Li, Wentao Sun, Chun Li. Engineered microorganisms and enzymes for efficiently synthesizing plant natural products[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 62-73.
DOI：

Wenqiang Li, Wentao Sun, Chun Li. Engineered microorganisms and enzymes for efficiently synthesizing plant natural products[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 62-73. DOI：

摘要

Abstract

Plant natural products are a kind of active substance widely used in pharmaceuticals and foods. However

the current production mode based on plant culture and extraction suffer complex processes and severe concerns for environmental and ecological. With the increasing awareness of environmental sustainability

engineered microbial cell factories have been an alternative approach to produce natural products. Many engineering strategies have been utilized in microbial biosynthesis of complex phytochemicals such as dynamic control and substructure engineering. Meanwhile

Enzyme engineering including directed evolution and rational design has been implemented to improve enzyme catalysis efficiency and stability as well as change promiscuity to expand product spectra. In this review

we discussed recent advances in microbial biosynthesis of complex phytochemicals from the following aspects

including pathway construction

strain engineering to boost the production.

关键词

Keywords

references

Views

232

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Mining and engineering of terpene synthases and their applications in biomanufacturing

Optimized anchor and cell wall engineering boost UDP-glycosyltransferase display for glycyrrhetinic acid glycosylation in Komagataella phaffii

Design of a rhodopsin-based light-driven proton pump to improve acid tolerance of yeast

Recent advances in the biosynthesis of natural products from C1 compounds

An international comprehensive benchmarking analysis of synthetic biology in China from 2015 to 2020

Related Author

Yue Xu

Chenwen Liu

Lei Qin

Bo Lv

Genlin Zhang

Chun Li

Li Chun

Liu Hu

Related Institution

Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology

State Key Laboratory of Green Biomanufacturing

Beijing Key Laboratory of Recombinant Protein Synthetic Biomanufacturing

Center for Synthetic and Systems Biology, Tsinghua University

Key Lab for Industrial Biocatalysis, Ministry of Education, Tsinghua University

⁰