Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

Ting-Ting Liu; Han Xiao; Jian-Hui Xiao; Jian-Jiang Zhong

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Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

Synthetic Biotechnology and Metabolic Engineering | Updated：2026-01-06

- Impact of oxygen supply on production of terpenoids by microorganisms: State of the art
- Chinese Journal of Chemical Engineering Vol. 29, Issue 2, Pages: 46-53(2021)
- Affiliations：
  
  1. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, Laboratory of Molecular Biochemical Engineering and Advanced Fermentation Technology, Department of Bioengineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University,Shanghai,China,200240
  2. Zunyi Municipal Key Laboratory of Medicinal Biotechnology, Center for Translational Medicine, Affiliated Hospital of Zunyi Medical University,Zunyi,China,563003
- Author bio：
- Funds：
- DOI：
  CLC：
- Published：2021
- Accepted：
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Ting-Ting Liu, Han Xiao, Jian-Hui Xiao, Jian-Jiang Zhong. Impact of oxygen supply on production of terpenoids by microorganisms: State of the art[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 46-53.
DOI：

Ting-Ting Liu, Han Xiao, Jian-Hui Xiao, Jian-Jiang Zhong. Impact of oxygen supply on production of terpenoids by microorganisms: State of the art[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 46-53. DOI：

摘要

Abstract

Terpenoids are a class of high value-added natural products with a variety of biological functions. Genetically engineered microorganisms

such as those of

Escherichia coli

and

Saccharomyces cerevisiae

have merits in producing plant or fungus-derived terpenoids

due to their mature genetic manipulation

simple nutrient demand and fast growth. Oxygen

as a key environmental factor

is particularly important to microbial metabolism and growth

and suitable oxygen supply is viewed as a prerequisite for realizing highly efficient production of terpenoids by engineered microorganisms. In this article

the role of oxygen in regulating terpenoid bioproduction is overviewed from the viewpoints of cellular carbon metabolism

energy metabolism and terpenoid anabolism. Strategies on adjusting oxygen availability to microorganisms

including genetic modification of cellular metabolism related with oxygen utilization

are summarized and discussed

to provide helpful information for further improvement of terpenoid biosynthesis by microbes.

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Related Author

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Related Institution

Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University

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