The external loop airlift reactor (EL-ALR) is widely used for gas-liquid reactions. It's advantage of good heat and mass transfer rates compared to conventional bubble column reactors. In the case of fermentation application where a medium is highly viscous and coalescing in nature

internal in riser helps in the improvement of the interfacial area as well as in the reduction of liquid-phase back mixing. The computational fluid dynamic (CFD) as a tool is used to design and scale-up of sectionalized external loop airlift reactor. The present work deals with computational fluid dynamics (CFD) techniques and experimental measurement of a gas hold-up

liquid circulation velocity

liquid axial velocity

Sauter mean bubble diameter over a broad range of superficial gas velocity 0.0024 ≤

U

G

≤ 0.0168 m·s

-1

. The correlation has been made for bubble size distribution with specific power consumption for different plate configurations. The effects of an internal on different mass transfer models have been completed to assess their suitability. The predicted local mass transfer coefficient has been found higher in the sectionalized external loop airlift reactor tha

n the conventional EL-ALR.