Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids ([OMIm][Br]+[HMIm][Br]+water) at different temperatures

Mohammad Barzegar-Jalali; Abolghasem Jouyban; Fleming Martinez; Hemayat Shekaari; Seyyedeh Narjes Mirheydari

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Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids ([OMIm][Br]+[HMIm][Br]+water) at different temperatures

Chemical Engineering Thermodynamics | Updated：2026-01-06

- Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids ([OMIm][Br]+[HMIm][Br]+water) at different temperatures
- Chinese Journal of Chemical Engineering Vol. 28, Issue 1, Pages: 198-207(2020)
- Affiliations：
  
  1. Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz,Iran
  2. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz,Iran
  3. Kimia Idea Pardaz Azarbayjan(KIPA) Science-Based Company, Tabriz University of Medical Sciences, Tabriz,Iran
  4. Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Cra. 30 No. 45-03, Bogotá,. C.,D,Colombia
  5. Department of Physical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz,Iran
  6. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz,Iran
- Author bio：
- Funds：
- DOI：
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- Published：2020
- Accepted：
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Mohammad Barzegar-Jalali, Abolghasem Jouyban, Fleming Martinez, Hemayat Shekaari, Seyyedeh Narjes Mirheydari. Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids ([OMIm][Br]+[HMIm][Br]+water) at different temperatures[J]. Chinese Journal of Chemical Engineering, 2020, 28(1): 198-207.
DOI：

Mohammad Barzegar-Jalali, Abolghasem Jouyban, Fleming Martinez, Hemayat Shekaari, Seyyedeh Narjes Mirheydari. Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids ([OMIm][Br]+[HMIm][Br]+water) at different temperatures[J]. Chinese Journal of Chemical Engineering, 2020, 28(1): 198-207. DOI：

摘要

Abstract

Experimental mole fraction solubility of lamotrigine (LTG) in ternary aqueous mixtures of two ionic liquids (ILs)

1-hexyl and 1-octyl-3-methylimidazolium bromide

[HMIm

]

[Br

]

and [OMIm

]

[Br

]

were reported at several temperatures

=(293.15 to 313.15) K. The van't Hoff and (Jouyban-Acree-van't Hoff

E-Jouyban-Acree-van't Hoff

e-NRTL

UNIQUAC and Wilson) models were used to correlate the solubility data. The comparison of the models with temperature and solvent composition dependencies shows that the Wilson model has the minimum ARD which are relatively close to those obtained from Jouyban-Acree-van't Hoff and E-Jouyban-Acree-van't Hoff models and maximum ARD belonged to the UNIQUAC model. The order of ARDs for these models is:Wilson Jouyban-Acree-van't Hoff

E-Jouyban-Acree-van't Hoff e-NRTL UNIQUAC. Moreover

the apparent thermodynamic functions

Gibbs free energy

enthalpy and entropy of dissolution and mixing were calculated based on the van't Hoff and Gibbs free energy equations. The strong LTG-ILs interactions and enthalpic contribution of the dissolution process resulted from the calculated thermodynamic functions.

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