In this paper

the solubility of 4-nitroimidazole in twelve pure solvents (toluene

benzene

1

4-dioxane

acetonitrile

ethyl acetate

acetone

GBL

ethanol

methanol

n

-butanol

DMF and NMP) were determined by using the laser monitoring system from 278.15 K to 323.15 K under 101.1 kPa

which are 0.00018-0.00070

0.00021-0.00073

0.00034-0.00092

0.00038-0.00142

0.00047-0.00120

0.00126-0.00303

0.00225-0.00517

0.00310-0.00724

0.00467-0.00982

0.00453-0.01940

0.01947-0.04652

and 0.04670-0.07452

respectively. At constant temperature

the mole fraction solubility of 4-nitroimidazole were increased as the following order: toluene benzene 1

4-dioxane (ethyl acetate or acetonitrile) acetone GBL ethanol (methanol or nbutanol) DMF NMP

and the solubility of 4-nitroimidazole in (ethyl acetate

acetonitrile) and (methanol

n

-butanol) had an intersection point at 297.55 K and 281.85 K

respectively. The solubility of 4-nitroimidazole could be increased with increasing temperature in twelve pure solvents. The ideal model

modified Apelblat equation

polynomial empirical equation

and

λh

equation were used to correlate the experimental values. The experimental s

olubility values were employed to calculate the standard dissolution enthalpy

standard dissolution entropy and Gibbs energy. The dissolution of 4-nitroimidazole could be an endothermic process in twelve pure solvents. The determination and fitting solubility of 4-nitroimidazole have important guiding significance for the purification and crystallization of its preparation process.