Preferential solvation of pomalidomide, an anticancer compound, in some binary mixed solvents at 298.15 K

Mohsen Padervand; Shima Naseri; Hadi Chahiyan Boroujeni

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Preferential solvation of pomalidomide, an anticancer compound, in some binary mixed solvents at 298.15 K

Chemical Engineering Thermodynamics | Updated：2026-01-06

- Preferential solvation of pomalidomide, an anticancer compound, in some binary mixed solvents at 298.15 K
- Chinese Journal of Chemical Engineering Vol. 28, Issue 10, Pages: 2626-2633(2020)
- Affiliations：
  
  1. Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh,Iran
  2. Department of Chemistry and Biology, Farhangian Teacher Training University, Mashhad Branch, Mashhad,Iran
- Author bio：
- Funds：
- DOI：
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- Published：2020
- Accepted：
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Mohsen Padervand, Shima Naseri, Hadi Chahiyan Boroujeni. Preferential solvation of pomalidomide, an anticancer compound, in some binary mixed solvents at 298.15 K[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2626-2633.
DOI：

Mohsen Padervand, Shima Naseri, Hadi Chahiyan Boroujeni. Preferential solvation of pomalidomide, an anticancer compound, in some binary mixed solvents at 298.15 K[J]. Chinese Journal of Chemical Engineering, 2020, 28(10): 2626-2633. DOI：

摘要

Abstract

Preferential solvation of pomalidomide (PMD) was explored in dimethyl sulfoxide (DMSO)-dimethylformamide (DMF)

DMSO-tetrahydrofuran (THF)

DMSO-methanol (MeOH)

DMSO-isopropanol

DMSO-water

water-DMF

water-THF

water-MeOH

and water-isopropanol binary mixed solvents at 298.15 K. Bosch-Rose model was utilized to determine the electronic transition energies (

) and other preferential solvation parameters

describing solute-solute and solute-solvent interactions. We found that

max

situation shifted with dielectric constant of the pure solvents meaningfully. According to the obtained results

enhanced and

max

shifted to the lower wavelengths as the percentage of DMSO decreased in the binary mixtures

remarking the important role of DMSO for stabilizing the excited state (π

) of PMD chromophore

via

efficient intermolecular solute-solvent interactions. In addition

the aqueous binary systems showed an optimum point for the

values as the percentage of water changed in the solutions. The local mole fraction of the solvents in the cybotactic region was also estimated to de

scribe the specific and non-specific interactions in the systems.

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