Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives

Qiao Chen; Fengxia Zou; Pengpeng Yang; Jingwei Zhou; Jinglan Wu; Wei Zhuang; Hanjie Ying

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Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives

Chemical Engineering Thermodynamics | Updated：2026-01-06

- Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives
- Chinese Journal of Chemical Engineering Vol. 26, Issue 10, Pages: 2112-2120(2018)
- Affiliations：
  
  1. 2 College of Biotechnology and Pharmaceutical Engineering, National Engineering Research Center for Biotechnology, Nanjing Tech University,Nanjing,China,210009
  2. 3 College of Chemistry and Chemical Engineering, Nantong University,Nantong,China,226019
- Author bio：
- Funds：
- DOI：
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- Published：2018
- Accepted：
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Qiao Chen, Fengxia Zou, Pengpeng Yang, Jingwei Zhou, Jinglan Wu, Wei Zhuang, Hanjie Ying. Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives[J]. Chin.J.Chem.Eng., 2018, 26(10): 2112-2120.
DOI：

Qiao Chen, Fengxia Zou, Pengpeng Yang, Jingwei Zhou, Jinglan Wu, Wei Zhuang, Hanjie Ying. Transformation of microstructure and phase of disodium guanosine 5'-monophosphate: Thermodynamic perspectives[J]. Chin.J.Chem.Eng., 2018, 26(10): 2112-2120. DOI：

摘要

Abstract

Microstructure and phase transformation of disodium guanosine 5'-monophosphate (5'-GMPNa

) are extremely important for controlling the process and understanding the mechanism of crystallization. In this work

the thermodynamic properties of polymorphous 5'-GMPNa

especially the solubility were studied

the solubility results show that 5'-GMPNa

is more soluble in ethanol-water (E-W) than in isopropanol-water (I-W). The amorphous form of 5'-GMPNa

is more soluble than the crystalline form at the same mole fraction and temperature. Meanwhile

the crystalline forms and morphologies of the residual solids were characterized by PXRD and SEM. The results indicate that solid forms of 5'-GMPNa

transformed spontaneously from amorphous to crystalline when the ethanol proportion is ≥ 20%. In addition

increasing the pH facilitates the dissolution of 5'-GMPNa

and helps to maintain the crystalline form. The associated Gibbs free energy values were calculated to verify the trend of transformation from amorphous to crystalline 5'-GMPNa

. These results should help to guide the industrial crystallization process and

to obtain the crystalline form of 5'-GMPNa

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