Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin

Jinglan Wu; Pengfei Jiao; Wei Zhuang; Jingwei Zhou; Hanjie Ying

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Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin

Separation Science and Engineering | Updated：2026-01-06

- Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin
- Chinese Journal of Chemical Engineering Vol. 24, Issue 10, Pages: 1386-1391(2016)
- Affiliations：
  
  1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University,Nanjing,China,211816
  2. National Engineering Technique Research Center for Biotechnology,Nanjing,China,211816
  3. Jiangsu National Synergetic Innovation Center for Advanced Material,Nanjing,China,210009
  4. State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing,China,210009
- Author bio：
- Funds：
- DOI：
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- Published：2016
- Accepted：
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Jinglan Wu, Pengfei Jiao, Wei Zhuang, Jingwei Zhou, Hanjie Ying. Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin[J]. , 2016, 24(10): 1386-1391.
DOI：

Jinglan Wu, Pengfei Jiao, Wei Zhuang, Jingwei Zhou, Hanjie Ying. Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin[J]. , 2016, 24(10): 1386-1391. DOI：

摘要

Abstract

L-phenylalanine

one of the nine essential amino acids for the human body

is extensively used as an ingredient in food

pharmaceutical and nutrition industries. A suitable equilibrium model is required for purification of L-phenylalanine based on ion-exchange chromatography. In this work

the equilibrium uptake of L-phenylalanine on a strong acid-cation exchanger SH11 was investigated experimentally and theoretically. A modified Donnan ion-exchange (DIX)model

which takes the activity into account

was established to predict the uptake of L-phenylalanine at various solution pH values. The model parameters including selectivity andmean activity coefficient in the resin phase are presented. The modified DIXmodel is in good agreementwith the experimental data. The optimum operating pH value of 2.0

with the highest L-phenylalanine uptake on the resin

is predicted by themodel. This basic information combined with the general mass transfer model will lay the foundation for the prediction of dynamic behavior of fixed bed separation process.

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