An iterative optimization strategy is proposed and applied to the steady state optimizing control of the bio-dissimilation process of glycerol to 1

3-propanediol in the presence of model-plant mismatch and input constraints. The scheme is based on the Augmented Integrated System Optimization and Parameter Estimation (AI-SOPE) technique

but a linearization of some performance function in the modified model-based optimization problem of AISOPE is introduced to overcome the difficulty of determining an appropriate penalty parameter. When carrying out the iterative optimization

the penalty coefficient is set to a larger value at the current iteration than at the previous iteration

which can promote the evolution rate of the iterative optimization. Simulation studies illustrate the potential of the approach presented for the optimizing control of the bio-dissimilation process of glyc-erol to 1

3-propanediol. The effects of measurement noise

measured and unmeasured disturbances on the proposed algorithm are also investigated.