Hydrophobic Pd/Al<sub>2</sub>O<sub>3</sub> catalyst intensified nitrobenzene hydrogenation in flow

Zhang Hongda; Hu Jinyan; Bao Shuting; Su Shichao; Yang Weiyao; Sang Le

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Hydrophobic Pd/Al₂O₃ catalyst intensified nitrobenzene hydrogenation in flow

Updated：2026-08-24

- Hydrophobic Pd/Al₂O₃ catalyst intensified nitrobenzene hydrogenation in flow
- Chinese Journal of Chemical Engineering Vol. 94, Issue 6, Pages: 92-101(2026)
- Affiliations：
  
  School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China
- Author bio：
  
  Corresponding author. E-mail address: lesang@bit.edu.cn(L. Sang)
- Funds：
- DOI：
  CLC：
- Received：13 September 2025，
  
  Revised：2026-01-11，
  
  Accepted：16 January 2026，
  
  Online First：14 February 2026，
  
  Published：2026-06
- Accepted：
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Zhang Hongda, Hu Jinyan, Bao Shuting, et al. Hydrophobic Pd/Al₂O₃ catalyst intensified nitrobenzene hydrogenation in flow[J]. Chinese Journal of Chemical Engineering, 2026, 94(6): 92-101.
DOI：

Zhang Hongda, Hu Jinyan, Bao Shuting, et al. Hydrophobic Pd/Al₂O₃ catalyst intensified nitrobenzene hydrogenation in flow[J]. Chinese Journal of Chemical Engineering, 2026, 94(6): 92-101. DOI：

摘要

Abstract

Designing efficient catalysts and solvent system for the multiphase hydrogenation reaction is vital in continuous flow reactors. Herein

we prepare hydrophilic Pd/Al

and hydrophobic modified C

PA-Pd/Al

catalyst for nitrobenzene (NB) hydrogenation in micropacked bed reactors (μPBRs). By tuning the methanol-water volume ratio

reaction

temperature

reaction pressure

liquid and gas superficial velocity

the NB conversion and aniline (AN) yield are optimized. The highest NB conversion of 97.1% and AN yield 95.6% are obtained in μPBRs with hydrophobic C

PA-Pd/Al

at the reaction temperature of 90℃. The apparent kinetic model is developed in μPBRs with two types of catalysts

and activity energies of NB hydrogenation for Pd/Al

and C

PA-Pd/Al

are 7.944 kJ·mol

- 1

and 3.372 kJ·mol

- 1

respectively. It indicates that the catalytic efficiency of C

PA-Pd/Al

is better than that of Pd/Al

in the methanol-water mixed solvent in μPBRs. The value of TOF for the hydrophobic modified C

PA-Pd/Al

catalyst is twice compared with the hydrophilic Pd/Al

catalyst. The value of STY for μPBRs is higher than that of stirred tank reactors (STRs) and fixed bed reactors (FBRs).

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Keywords

references

L.L. Zhang, M.X. Zhou, A.Q. Wang, T. Zhang, Selective hydrogenation over supported metal catalysts: from nanoparticles to single atoms, Chem. Rev. 120 (2) (2020) 683-733.

S. Kar, H. Sanderson, K. Roy, E. Benfenati, J. Leszczynski, Green chemistry in the synthesis of pharmaceuticals, Chem. Rev. 122 (3) (2022) 3637-3710.

M. Turáková, T. Salmi, K. Eränen, J. Wärnå, D.Y. Murzin, M. Králik, Liquid phase hydrogenation of nitrobenzene, Appl. Catal. Gen. 499 (2015) 66-76.

E. Masson, E.M. Maciejewski, K.M.P. Wheelhouse, L.J. Edwards, Fixed bed continuous hydrogenations in trickle flow mode: a pharmaceutical industry perspective, Org. Process Res. Dev. 26 (8) (2022) 2190-2223.

Y.Y. Ren, Y.S. Yang, M. Wei, Recent advances on heterogeneous non-noble metal catalysts toward selective hydrogenation reactions, ACS Catal. 13 (13) (2023) 8902-8924.

Y.W. Fan, P.X. Wang, J.H. Zhang, M.M. Huang, W. Liu, Y.L. Xu, X.N. Duan, Y.Y. Li, J.S. Zhang, Continuous hydrogenation of N-ethylcarbazole in a micropacked bed reactor for hydrogen storage, Chem. Eng. J. 484 (2024) 149404.

W.Y. Yang, R.X. Zhang, X.F. Zheng, Z.P. Zhao, L. Sang, Highly-efficient synthesis of 5-Hydroxymethylfurfural from fructose in micropacked bed reactors: multiphase transport, reaction optimization, and heterogeneous kinetic study, Chem. Eng. J. 497 (2024) 154 863.

C.X. Yang, A.R. Teixeira, Y.X. Shi, S.C. Born, H.K. Lin, Y. Li Song, B. Martin, B. Schenkel, M. Peer Lachegurabi, K.F. Jensen, Catalytic hydrogenation of N-4-nitrophenyl nicotinamide in a micro-packed bed reactor, Green Chem. 20 (4) (2018) 886-893.

C.H. Zhang, J. Luo, B.Q. Xie, W. Liu, J.S. Zhang, Green and continuous aerobic oxidation of ethylbenzene over homogeneous and heterogeneous NHPI in a micro-packed bed reactor, Chem. Eng. J. 468 (2023) 143674.

T. Zhou, J.Y. Hu, H.D. Zhang, H.S. Li, L. Sang, CO 2 absorption enhancement with MEA in micropacked bed reactors: mass transfer experiment and model study, Sep. Purif. Technol. 339 (2024) 126722.

Q. Cao, L. Sang, J.C. Tu, Y.S. Xiao, N. Liu, L.D. Wu, J.S. Zhang, Rapid degradation of refractory organic pollutants by continuous ozonation in a micro-packed bed reactor, Chemosphere 270 (2021) 128621.

C.T. Hu, R.L. Hartman, High-throughput packed-bed microreactors with inline analytics for the discovery of asphaltene deposition mechanisms, AIChE J. 60 (10) (2014) 3534-3546.

X.N. Duan, J.C. Tu, A.R. Teixeira, L. Sang, K.F. Jensen, J.S. Zhang, An automated flow platform for accurate determination of gas-liquid-solid reaction kinetics, React. Chem. Eng. 5 (9) (2020) 1751-1758.

L. Sang, X.D. Feng, J.C. Tu, B.Q. Xie, G.S. Luo, J.S. Zhang, Investigation of external mass transfer in micropacked bed reactors, Chem. Eng. J. 393 (2020) 124793.

L. Duan, C. Ma, F.Y. Lou, J.B. Yin, L. Sang, J.S. Zhang, Investigation of external mass transfer in a micropacked bed reactor with a Pd/Al 2 O 3 /nickel foam, Ind. Eng. Chem. Res. 61 (36) (2022) 13710-13719.

L. Duan, H.D. Zhang, M.M. Huang, L. Sang, J.S. Zhang, External mass transfer performance studies in a micropacked bed reactor with Pd/PDA/nickel foam, Ind. Eng. Chem. Res. 63 (28) (2024) 12385-12393.

X.N. Duan, J.B. Yin, M.M. Huang, A.X. Feng, W.S. Fu, H.X. Chen, Z.F. Huang, Y. G. Ding, J.S. Zhang, Hydrogenation kinetics of m -dinitrobenzene in a continuous micro-packed bed reactor, Chem. Eng. Sci. 248 (2022) 117113.

G. Chen, X. Zhu, R. Chen, Q. Liao, D.D. Ye, H. Feng, J. Liu, M. Liu, Gas-liquid-solid monolithic microreactor with Pd nanocatalyst coated on polydopamine modified nickel foam for nitrobenzene hydrogenation, Chem. Eng. J. 334 (2018) 1897-1904.

G. Chen, X. Zhu, R. Chen, Q. Liao, D.D. Ye, H. Feng, J. Liu, M. Liu, K. Wang, Structured Ni-B amorphous alloy catalysts on Ni foam for a gas-liquid-solid microreactor, Catal. Sci. Technol. 10 (6) (2020) 1933-1940.

A. Rahmani, T.M. Currie, L.R. Shultz, J.T. Bryant, M.J. Beazley, F.J. Uribe-Romo, L. Tetard, N.G. Rudawski, S.H. Xie, F .D. Liu, T.H. Wang, T.G. Ong, L. Zhai, T. Jurca, Robust palladium catalysts on nickel foam for highly efficient hydrogenations, Catal. Sci. Technol. 12 (23) (2022) 6992-6997.

C. Ma, W. Liu, X.N. Duan, C.H. Zhang, L. Sang, J.S. Zhang, Preparation of highly effective Ni foam monolithic catalysts by electrolytic deposition for nitrobenzene hydrogenation in a micropacked bed, Ind. Eng. Chem. Res. 61 (30) (2022) 11276-11287.

X. Li, X.M. Ren, M. Guo, W.J. Li, Q.H. Yang, Water accelerated activity of Ru NPs in sequential hydrogenation of nitrobenzene to cyclohexylamine, J. Catal. 413 (2022) 546-553.

D.P. Fapojuwo, C.O. Oseghale, C.A. Akinnawo, R. Meijboom, Bimetallic PdM (M = Co, Ni) catalyzed hydrogenation of nitrobenzene at the water/oil interface in a pickering emulsion, Colloids Surf. A Physicochem. Eng. Aspects 619 (2021) 126513.

F.J. Navarro-Brull, R. Gómez, Modeling pore-scale two-phase flow: how to avoid gas-channeling phenomena in micropacked-bed reactors via catalyst wettability modification, Ind. Eng. Chem. Res. 57 (1) (2018) 84-92.

H.D. Zhang, W.Y. Yang, M. Pang, Y.Q. Tian, S.C. Su, Z.P. Zhao, L. Sang, Hydrophobic Ni foam catalyst for nitrobenzene hydrogenation enhancement in micropacked bed reactors, AIChE J. 71 (7) (2025) e18846.

L.S. Zhang, A.G. Zhou, B.R. Sun, K.S . Chen, H.Z. Yu, Functional and versatile superhydrophobic coatings via stoichiometric silanization, Nat. Commun. 12 (1) (2021) 982.

D. Zhang, X.G. Zeng, C.Y. Wen, H. Luo, Y. Guo, Fluorinated silane induced zincophilic-hydrophobic interface for stable Zn anode, Surf. Interfaces 56 (2025) 105734.

P.X. Hao, D.K. Schwartz, J.W. Medlin, Phosphonic acid promotion of supported Pd catalysts for low temperature vanillin hydrodeoxygenation in ethanol, Appl. Catal. Gen. 561 (2018) 1-6.

L. Lv, M. Zhao, Y.N. Liu, Y.F. He, D.Q. Li, Fabrication of hydrophobic Pd/Al 2 O 3 -phosphoric acid via POAl bond for liquid hydrogenation reaction, Chin. J. Chem. Eng. 53 (2023) 232-242.

C. Verma, M.A. Quraishi, K.Y. Rhee, Hydrophilicity and hydrophobicity consideration of organic surfactant compounds: effect of alkyl chain length on corrosion protection, Adv. Colloid Interface Sci. 306 (2022) 102723.

C.T. Wang, Z.Q. Liu, L. Wang, X. Dong, J. Zhang, G.X. Wang, S.C. Han, X.J. Meng, A. M. Zheng, F.S. Xiao, Importance of zeolite wettability for selective hydrogenation of furfural over Pd@Zeolite catalysts, ACS Catal. 8 (1) (2018) 474-481.

J.L. Yong, F. Chen, Y. Fang, J.L. Huo, Q. Yang, J.Z. Zhang, H. Bian, X. Hou, Bioinspired design of underwater superaerophobic and superaerophilic surfaces by femtosecond laser ablation for anti-or capturing bubbles, ACS Appl. Mater. Interfaces 9 (45) (2017) 39863-39871.

H.D. Zhang, M. Pang, W.Y. Yang, L. Sang, Z.P. Zhao, Controllable wettability on Ni foam with PDA coatings and gas-liquid mass transfer enhancement in micropacked bed reactors, Chem. Eng. Sci. 302 (2025) 120892.

H.J. Wang, Y. Wang, Y.F. Li, X.C. Lan, B. Ali, T.F. Wang, Highly efficient hydrogenation of nitroarenes by N-doped carbon-supported cobalt single-atom catalyst in ethanol/water mixed solvent, ACS Appl. Mater. Interfaces 12 (30) (2020) 34021-34031.

X.Y. Liu, M.Y. Zhang, X. Liu, J.L. Liu, H.C. Dai, W.H. Luo, J. Liu, R. Gao, Q.H. Yang, Regulation of the properties of hydrogen dissociation and transfer in the presence of S atoms for efficient hydrogenations, ACS Catal. 14 (21) (2024) 16214-16223.

N. Dimitratos, G. Vilé, S. Albonetti, F. Cavani, J. Fiorio, N. López, L.M. Rossi, R. Wojcieszak, Strategies to improve hydrogen activation on gold catalysts, Nat. Rev. Chem 8 (3) (2024) 195-210.

X.N. Duan, J.B. Yin, M.M. Huang, P.X. Wang, J.S. Zhang, Hydrogenation kinetics of halogenated nitroaromatics over Pt/C in a continuous Micro-packed bed reactor, Chem. Eng. Sci. 251 (2022) 117483.

H.B. Wang, T. Zhou, S.P. Han, L. Duan, L. Sang, Z.P. Zhao, Hydrodynamics and mass transfer enhancement of gas-liquid flow in micropacked bed reactors:effect of contact angle, AIChE J. 69 (2) (2023) e17846.

J.Y. Wang, J. Yang, B. Sundén, Q.W. Wang, Assessment of flow pattern and temperature profiles by residence time distribution in typical structured packed beds, Numer. Heat Tran. 77 (6) (2020) 559-578.

L. Duan, M.M. Huang, Z.P. Peng, L. Sang, J.S. Zhang, Efficient and continuous furfural hydrogenation to furfuryl alcohol in a micropacked bed reactor, React. Chem. Eng. 8 (7) (2023) 1719-1728.

J.C. Tu, L. Sang, H. Cheng, N. Ai, J.S. Zhang, Continuous hydrogenolysis of N -diphenylmethyl groups in a micropacked-bed reactor, Org. Process Res. Dev. 24 (1) (2020) 59-66.

X. Li, H. Li, C.Z. Li, M.D. Wang, Q.H. Yang, Tuning the surface wettability of Pd/COFs for selective hydrogenation, ChemCatChem 15 (12) (2023) e202300002.

P.P. Zuo, J.Q. Duan, H.L. Fan, S.J. Qu, W.Z. Shen, Facile synthesis high nitrogendoped porous carbon nanosheet from pomelo peel and as catalyst support for nitrobenzene hydrogenation, Appl. Surf. Sci. 435 (2018) 1020-1028.

X.J. Zhao, X.X. Lu, W.J. Chen, Y.B. Liu, X.Y. Pan, Palladium decoration directed synthesis of ZIF-8 nanocubes with efficient catalytic activity for nitrobenzene hydrogenation, Dalton Trans. 51 (29) (2022) 10847-10851.

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Hydrophobic Pd/Al2O3 catalyst intensified nitrobenzene hydrogenation in flow

DOI：

摘要

Abstract

关键词

Keywords

references

Hydrophobic Pd/Al₂O₃ catalyst intensified nitrobenzene hydrogenation in flow