SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2018, Vol. 26 ›› Issue (6): 1430-1434.doi: 10.1016/j.cjche.2018.02.030

• General reactor • 上一篇    下一篇

Stability of penicillin G in ionic liquid [Bmim]PF6

Jingxian Qi, Qingfen Liu, Huizhou Liu   

  1. CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
  • 收稿日期:2017-11-30 修回日期:2018-02-08 出版日期:2018-06-28 发布日期:2018-08-03
  • 通讯作者: Qingfen Liu,E-mail address:qfliu@ipe.ac.cn;Huizhou Liu,E-mail address:hzliu@ipe.ac.cn E-mail:qfliu@ipe.ac.cn;hzliu@ipe.ac.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China (21676272); Major Science and Technology Project of Water Pollution Control and Management in China (2017ZX07402003) and the Key Research Program of the Chinese Academy of Sciences (ZDRW-ZS-2016-5-3).

Stability of penicillin G in ionic liquid [Bmim]PF6

Jingxian Qi, Qingfen Liu, Huizhou Liu   

  1. CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2017-11-30 Revised:2018-02-08 Online:2018-06-28 Published:2018-08-03
  • Contact: Qingfen Liu,E-mail address:qfliu@ipe.ac.cn;Huizhou Liu,E-mail address:hzliu@ipe.ac.cn E-mail:qfliu@ipe.ac.cn;hzliu@ipe.ac.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China (21676272); Major Science and Technology Project of Water Pollution Control and Management in China (2017ZX07402003) and the Key Research Program of the Chinese Academy of Sciences (ZDRW-ZS-2016-5-3).

摘要: The extraction of penicillin G by ionic liquid [Bmim]PF6 has exhibited promising prospect. The stability of penicillin G is crucial for developing a green ionic liquid-based extraction technology. In this work, the stability of penicillin G in [Bmim]PF6 was systematically investigated. The results showed the stability of penicillin G was significantly influenced by pH and temperature. It tended to be more stable when pH value increased from 1.5 to 4.0 and the temperature gradually decreased. The half-life (t1/2) of penicillin G in [Bmim]PF6 was 17.7 h in the optimal technological condition (pH 2.0 and 10℃), which is enough for the requirement of extraction technology. The reaction of penicillin G in [Bmim]PF6 followed the first order kinetics in the pH range 2.0-4.0. Three isomers of penicillin G were found through rearrangement at pH 2.0, and their structures were not affected by temperature.

关键词: Penicillin G, Ionic liquids, Stability, Rearrangement, Kinetics

Abstract: The extraction of penicillin G by ionic liquid [Bmim]PF6 has exhibited promising prospect. The stability of penicillin G is crucial for developing a green ionic liquid-based extraction technology. In this work, the stability of penicillin G in [Bmim]PF6 was systematically investigated. The results showed the stability of penicillin G was significantly influenced by pH and temperature. It tended to be more stable when pH value increased from 1.5 to 4.0 and the temperature gradually decreased. The half-life (t1/2) of penicillin G in [Bmim]PF6 was 17.7 h in the optimal technological condition (pH 2.0 and 10℃), which is enough for the requirement of extraction technology. The reaction of penicillin G in [Bmim]PF6 followed the first order kinetics in the pH range 2.0-4.0. Three isomers of penicillin G were found through rearrangement at pH 2.0, and their structures were not affected by temperature.

Key words: Penicillin G, Ionic liquids, Stability, Rearrangement, Kinetics