SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2018, Vol. 26 ›› Issue (2): 252-258.doi: 10.1016/j.cjche.2017.04.003

• Separation Science and Engineering • 上一篇    下一篇

Dissolution of antibiotics mycelium in ionic liquids: Performance and mechanism

Jierong Yang1,2, Wangliang Li1, Qingfen Liu1, Huizhou Liu1   

  1. 1 Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
    2 University of Chinese Academy of Sciences, Beijing 100049, China
  • 收稿日期:2017-03-28 修回日期:2017-04-01 出版日期:2018-02-28 发布日期:2018-03-16
  • 通讯作者: Qingfen Liu, Huizhou Liu E-mail:qfliu@ipe.ac.cn;hzliu@ipe.ac.cn
  • 基金资助:

    Supported by the National Natural Science Foundation of China (21676272), the Major Science and Technology Program for Water Pollution Control and Treatment (2017ZX07402003) and the Key Research Program of the Chinese Academy of Sciences (ZDRW-ZS-2016-5-3).

Dissolution of antibiotics mycelium in ionic liquids: Performance and mechanism

Jierong Yang1,2, Wangliang Li1, Qingfen Liu1, Huizhou Liu1   

  1. 1 Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
    2 University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2017-03-28 Revised:2017-04-01 Online:2018-02-28 Published:2018-03-16
  • Contact: Qingfen Liu, Huizhou Liu E-mail:qfliu@ipe.ac.cn;hzliu@ipe.ac.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China (21676272), the Major Science and Technology Program for Water Pollution Control and Treatment (2017ZX07402003) and the Key Research Program of the Chinese Academy of Sciences (ZDRW-ZS-2016-5-3).

摘要: Antibiotics mycelium, byproduct of pharmaceutical industry, contains high percentage of proteins, polysaccharides and lipids, while, the low solubility in traditional solvents limits its utilization. The dissolution process of penicillin mycelium was investigated using ionic liquids (ILs) as solvent. Quantitative correlation of solubility and ILs structure and dissolution mechanism were determined. About 91.45% of penicillin mycelium was dissolved in 1-butyl-3-methylimidazolium acetate ([Bmim] Ac) under the condition of 120.0℃ and[Bmim]Ac/mycelium (m/m) ratio of 3.90:1. Synergistic effect of ILs and DMSO was confirmed with the DMSO/[Bmim] Ac (v/m) ratio in the range of 0.0-1.0. At 25.0℃, the dissolution of penicillin mycelium increased from 69.74% to 94.50%, with the ratio of DMSO to[Bmim] Ac (v/m) as 1:1. The room temperature dissolution of mycelium provides a novel and energy-saving process for its high-valued utilization. The NMR and FT-IR spectra showed that hydrogen bonds are the dominant driving force for the dissolution in ILs. Quantitative study on the effects of anions and cations of ILs on dissolution using Kamlet-Taft model showed that there was a linearly positive correlation between solubility of penicillin mycelium and β parameter of the ILs. The solubility of mycelium increased with increasing hydrogen bond accepting ability of anions and donating ability of cations.

关键词: Antibiotics mycelium, Ionic liquids, Dissolution, Driving force, Kamlet-Taft parameters

Abstract: Antibiotics mycelium, byproduct of pharmaceutical industry, contains high percentage of proteins, polysaccharides and lipids, while, the low solubility in traditional solvents limits its utilization. The dissolution process of penicillin mycelium was investigated using ionic liquids (ILs) as solvent. Quantitative correlation of solubility and ILs structure and dissolution mechanism were determined. About 91.45% of penicillin mycelium was dissolved in 1-butyl-3-methylimidazolium acetate ([Bmim] Ac) under the condition of 120.0℃ and[Bmim]Ac/mycelium (m/m) ratio of 3.90:1. Synergistic effect of ILs and DMSO was confirmed with the DMSO/[Bmim] Ac (v/m) ratio in the range of 0.0-1.0. At 25.0℃, the dissolution of penicillin mycelium increased from 69.74% to 94.50%, with the ratio of DMSO to[Bmim] Ac (v/m) as 1:1. The room temperature dissolution of mycelium provides a novel and energy-saving process for its high-valued utilization. The NMR and FT-IR spectra showed that hydrogen bonds are the dominant driving force for the dissolution in ILs. Quantitative study on the effects of anions and cations of ILs on dissolution using Kamlet-Taft model showed that there was a linearly positive correlation between solubility of penicillin mycelium and β parameter of the ILs. The solubility of mycelium increased with increasing hydrogen bond accepting ability of anions and donating ability of cations.

Key words: Antibiotics mycelium, Ionic liquids, Dissolution, Driving force, Kamlet-Taft parameters